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Lactate, the end product of glycolysis, functions not merely as a metabolic byproduct but as a signaling molecule that promotes fibrosis through histone lactylation and modulation of gene expression (28,35)

27 DooleyS.HamzaviJ.BreitkopfK.WiercinskaE.SaidH

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8 Lipid peroxidation associated with ferroptosis initiates on internal membranes and subsequently appears at the plasma membrane, leading to ion imbalances and increased membrane permeability

Funding This work was supported by Italian Association for Cancer Research (IG15232 to CR

Gillum, A